BACKGROUND: The epidermal growth factor receptor kinases, or ErbB kinases, belong to a large sub-group of receptor tyrosine kinases (RTKs), which share a conserved catalytic core.The catalytic core of ErbB kinases have functionally diverged from other RTKs in that they are activated by a unique allosteric mechanism that involves specific interactio
Several clinical trials have proven that immunotherapy can improve survival and benefit non-small cell lung cancer (NSCLC) patients.In patients who progress after chemotherapy, immune checkpoint inhibitor (ICI) monotherapy can prolong overall survival compared with patients receiving single-agent ventilationstejp chemotherapy.A 61-year-old man diag
A 1.0 KVA fuelless generator has been developed.The crave for sustainable energy solution has led to the exploration of emerging technologies targeted at reducing reliance on fossil fuels and reducing environmental impact.One such technology is the development of fuelless generators, which harness renewable energy sources or utilize unconventional
Congregational leaders in the US must navigate a political landscape marked by increasing political polarization and a notable rise in support for ideas aligned with Christian nationalism.While gender, race, ethnicity, and religious affiliation have long shaped political lines, the US population has steadily become more entrenched in partisan polit
Objective To investigate the prevalence of cardiometabolic risk factors (CMRFs), target organ damage (TOD) and its associated factors among adults in Freetown, Sierra Leone.Design This community-based cross-sectional study used a stratified multistage random sampling method to recruit adult participants.Setting The health screening study was conduc